In 2016, nearly 16.2 million adults in the United States experienced at least one major depression. Scientists around the world are working to reduce the mortality and morbidity associated with this disease. A recent study published in JAMA Psychiatry linked some of the neural mechanisms to recurrence of depression, suggesting that focusing on certain areas of the nerve helps to understand the prognosis of the disease.
According to the author, Mary L. Phillips, despite the prevalence, the recurrence rate of major depression [MDD] is high and the remission rate is low. Unfortunately, there is a lack of research in understanding the neural mechanisms that increase an individual's propensity for MDD. She adds that understanding certain pathophysiological pathways that make people susceptible to MDD can help identify neural markers that might be used to develop personalized intervention strategies. In addition, knowledge of these neural mechanisms can prevent or prevent recurrence in high-risk patients. Phillips mentioned a German study that tried to bridge this gap.
Recurrence occurs when gray matter regulates mood reduction
Dario Zaremba and his colleagues conducted a small study that examined the entire brain region and region, with changes in gray matter volume and cortical thickness for two years. The study population included 60 patients with MDD and 54 healthy individuals.
Researchers used whole-brain voxel-based morphometry to study the gray matter volume of patients and areas with varying cortical thickness. During follow-up, participants were divided into two groups - those who did not relapse and those who relapsed at least once. Outside the pool, 37 people were put in the latter.
Phillips explained the results and pointed out that recurrence is associated with a reduction in gray matter in the neuronal region, which is related to physical regulation, highlighting processing and executive function. Most likely, it occurs because of changes in glial cell density or neuron size. She also noted that at baseline, there was a lack of correlation between symptom severity at follow-up and drug load at gray matter volume. She added that this is the first time that an objective neural marker has been identified to track MDD in future middle-aged populations.
Philips emphasizes that Zaremba's research is unique because it focuses on high recurrence rates and assessing the challenges of disease progression. She further writes that this study may help identify neuroimaging techniques as a potential tool for building long-term treatment plans and provide better outcomes for people with MDD.
Recovery from depression is possible
Depression can be treated with drugs and psychotherapy, such as cognitive behavioral therapy [CBT] and dialectical behavioral therapy [DBT]. In addition, individual and group therapies also play a key role in relieving symptoms. Patients are also encouraged to maintain a healthy balance between physical and mental health by focusing on diet, physical exercise, relaxation of psychological skills and pursuit of interest.
Orignal From: Studies have found a link between neurobiomarkers and relapse of depression
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